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pentobarbital will decrease the level or impact of larotrectinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases results of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of CYP3A4 inducers might decrease sufentanil concentrations and efficacy